A new Mayo Clinic chew over suggests immediate relatives (brother sister care father son or daughter) of people who have Parkinson’s disease are at increased risk for developing depression and anxiety disorders. According to the authors the assay is particularly increased in families of patients who develop Parkinson’s disease before age 75.
“Studies by our assort and others undergo shown that relatives of patients with Parkinson’s disease have an increased risk of Parkinson’s disease,” explains Walter Rocca. M. D. senior author of the study and a Mayo Clinic neurologist and epidemiologist.
“Recently we showed they also have increased assay of essential tremor and of cognitive impairment or dementia. However their assay of psychiatric disorders was unknown.
“Because many patients with Parkinson’s disease develop anxiety and depression after and even before the onset of the disease we explored whether this tendency was show to a greater extent in family members of people with Parkinson’s disease compared with people without the disease. We found that indeed relatives of patients with Parkinson’s disease are at increased risk for anxiety and depressive disorders which suggests a genetic or other relationship between those disorders and Parkinson’s disease.”
Dr. Rocca emphasizes that the familial susceptibility factors may be genetic environmental or a combination of the two and that advance investigate is needed to determine their exact nature.
Significance of the Mayo Clinic ResearchThis is the first large population-based study to show that Parkinson’s disease and psychiatric disorders may overlap familial factors that make a person susceptible to developing one or both. An important methodological feature of the chew over is that researchers assessed each family member individually rather than having one relative provide information for the entire family.
•1,000 immediate relatives of 162 patients with Parkinson’s disease from Olmsted County. Minn. where Mayo Clinic’s Rochester campus is located•850 first-degree relatives of 147 “matched controls” from the same Olmsted County population — the controls were similar in age and of the same gender as the patients in the first assort but did not have Parkinson’s disease
The investigators used the medical records-linkage system of the Rochester Epidemiology Project to determine subjects with Parkinson’s disease and the control subjects and to obtain clinical information about psychiatric diseases for relatives in both groups who lived part or all of their lives in Olmsted County. Housed at Mayo Clinic the Rochester Epidemiology communicate is one of the largest long-term integrated databases of patient records in the world.
Documentation of psychiatric disorders for relatives was obtained by a direct converse whenever possible (or by an interview with their proxy for those who had died prior to the chew over or were incapacitated) and through a analyse of their medical record.
Psychiatric disorders in the medical records were defined using published clinical criteria or physician diagnosis. Diagnoses were verified by a neurologist and a psychiatrist at Mayo Clinic who were not told whether the record was from a relative of a patient with Parkinson’s disease or from a relative of a control subject.
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Related article:
http://psychcentral.com/news/2007/12/04/mental-disorders-among-parkinsons-family-members/1609.html
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